Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation
نویسندگان
چکیده
منابع مشابه
Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm.
Prolonged mechanical ventilation (MV) results in diaphragmatic weakness due to fiber atrophy and contractile dysfunction. Recent work reveals that activation of the proteases calpain and caspase-3 is required for MV-induced diaphragmatic atrophy and contractile dysfunction. However, the mechanism(s) responsible for activation of these proteases remains unknown. To address this issue, we tested ...
متن کاملMechanical ventilation-induced oxidative stress in the diaphragm.
Prolonged mechanical ventilation (MV) results in oxidative damage in the diaphragm; however, it is unclear whether this MV-induced oxidative injury occurs rapidly or develops slowly over time. Furthermore, it is unknown whether both soluble (cytosolic) and insoluble (myofibrillar) proteins are equally susceptible to oxidation during MV. These experiments tested two hypotheses: 1). MV-induced ox...
متن کاملDepression of diaphragm motor cortex excitability during mechanical ventilation.
The effect of mechanical ventilation on the diaphragm motor cortex remains unknown. We assessed the effect of mechanical ventilation on diaphragm motor cortex excitability by measuring the costal and crural diaphragm motor-evoked potential (MEP) elicited by single and paired transcranial magnetic stimulation. In six healthy subjects, MEP recruitment curves of the costal and crural diaphragms we...
متن کاملRedox regulation of diaphragm proteolysis during mechanical ventilation.
Prevention of oxidative stress via antioxidants attenuates diaphragm myofiber atrophy associated with mechanical ventilation (MV). However, the specific redox-sensitive mechanisms responsible for this remain unknown. We tested the hypothesis that regulation of skeletal muscle proteolytic activity is a critical site of redox action during MV. Sprague-Dawley rats were assigned to five experimenta...
متن کامل[Prolonged mechanical ventilation probability model].
OBJECTIVE To design a probability model for prolonged mechanical ventilation (PMV) using variables obtained during the first 24 hours of the start of MV. DESIGN An observational, prospective, multicenter cohort study. SCOPE Thirteen Spanish medical-surgical intensive care units. PATIENTS Adult patients requiring mechanical ventilation for more than 24 hours. INTERVENTIONS None. STUDY ...
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ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 2009
ISSN: 0090-3493
DOI: 10.1097/ccm.0b013e31819cef63